demyelination
英[diːˌmaɪələ'neɪʃən]
美[diːˌmaɪələ'neɪʃən]
- n. [医]髓鞘脱夫；脱髓鞘
sclerosis硬化; lesion损害; ischemia局部缺血; neurodegenerative组织退化; neuronal元; edema瘤腺体; autoimmune自身免疫; atrophy萎缩，萎缩症; inflammation炎症; apoptosis细胞死; neuropathy病;
详细释义
Noun:
-
loss of the myelin covering of some nerve fibers resulting in their impaired function
双语例句
- 1. Active foci of demyelination may demonstrate restricted diffusion.
- 脱髓鞘的活动性的病灶可以显示为弥散受限。
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- 2. Demyelination of white matter fibers caused by arteriopathy is one of the major causes of leukoaraiosis.
- 小动脉病变导致的白质纤维脱髓鞘是发生白质疏松的主要原因之一。
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- 3. In our case, the thin peripheral rim of restricted diffusion may represent an active edge of demyelination.
- 在我们的病例中，周边的弥散受限的薄壁环状影可能代表脱髓鞘病变的活动性边缘。
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- 4. Reactive oxygen species (ROS) are mediators of demyelination and disruption of the blood-brain barrier (BBB).
- 活性氧簇(ROS)是神经系统脱髓鞘及血脑屏障破坏的媒介。
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- 5. Mild myelinic degeneration was present in both cerebrum and cerebellum, and no typical demyelination was seen.
- 大鼠大脑及小脑髓鞘轻度变性，但未见典型脱髓鞘改变。
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- 6. Then, they studied mice that lacked PrP in some cells but not in others to see which cells were behind the demyelination.
- 然后，他们又研究在不同细胞里缺乏PrP的老鼠们，以期找到哪个细胞是脱髓鞘作用发生的根源。
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- 7. The enhancing rim is felt to represent the leading edge of demyelination, and therefore usually faces the white matter.
- 强化环代表脱髓鞘的前缘，因此通常面对白质。
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- 8. To further investigate the relation of variety cell in brain tissue to demyelination, this experiment was performed on 12 dogs with canine distemper.
- 为了进一步调查神经纤维的脱髓与脑细胞成份的关系，用12只患犬瘟热的自然病例进行了本实验。
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- 9. The result showed: (1) In the same patient alone, the demyelination in the diseased nerve branch was even more serious than that in the undiseased one.
- 结果发现：（1）同是取自三叉神经痛患者，远颅端患支的脱髓鞘程度较未发病的正常神经更严重；
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- 10. The hyperintense bands on T2 weighted images correspond to concentric bands of demyelination with gliosis and perivascular lymphocytic infiltration (5).
- T2高信号带符合伴有胶质增生和淋巴细胞浸润的脱髓鞘同心环结构。
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- 11. In classic PMD, the MRI findings tend to be stable or mildly progressive over years since the primary problem is hypomyelination rather than demyelination.
- 在经典型PMD中，MRI异常改变在多年后都保持稳定或仅有轻微的进展，这是因为其病因在于髓鞘形成不良而不是脱髓鞘。
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- 12. Seen here in white matter is a large "plaque" of demyelination. The plaque has a grey-tan appearance. Such plaques are typical for multiple sclerosis (MS).
- 在白质上看到的是脱髓鞘的大“斑块”，斑块呈灰褐色外观，是多发性硬化症(MS)的典型表现。
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- 13. The myelin sheath of the sciatic nerve was characterized by edema of different degrees, vacuole-like denaturation, structural derangement and local demyelination.
- 坐骨神经的髓鞘存在不同程度的水肿，空泡样变性，结构紊乱和局灶性脱失。
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- 14. But no variant of prion protein was able to prevent demyelination when introduced specifically into the Schwann cells that surround and support peripheral nerve cells.
- 但当向神经末梢周围的雪旺细胞注入这种蛋白时，没有变异的蛋白能阻止退化。
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- 15. Conclusion: GBE can delay demyelination process in EAE mice by inhibiting microglial activation, suggesting that GBE has potential to treat multiple sclerosis in future.
- 结论：GBE可能通过抑制小胶质细胞激活从而延缓EAE小鼠脱髓鞘进程，提示GBE对多发性硬化具有一定的治疗作用。
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- 16. It was related to the dosage and time. Along with the time extension and the cuprizone dosage increasement, the cell apoptosis increased and the demyelination aggravated.
- 结论环己酮草酰二腙可诱导大鼠脑白质脱髓鞘、空泡样变，呈时间剂量相关性，随着时间延长和累积剂量增加，细胞凋亡及空泡形成增多；
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- 17. "Schwann cells have been proposed as a cell type for treatment of nerve injuries, demyelination disorders such as multiple sclerosis, and even spinal cord injury, " said Dr.
- 施万细胞很早就被看作用来治疗神经损伤和脱髓鞘紊乱性疾病，例如多器官硬化病，甚至脊髓损伤。
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- 18. The results also showed that degree of demyelination of branches of sciatic nerve were different and possibly associated with curled toe paralysis or no curled toe paralysis.
- 此外，本实验发现坐骨神经干的不同分支脱髓鞘程度不同，并提出此变化与病鸡是否表现卷趾麻痹密切相关。
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- 19. Administration of the RXR agonist 9-cis-retinoic acid to demyelinated cerebellar slice cultures and to aged rats after demyelination caused an increase in remyelinated axons.
- 向脱髓鞘的小脑切片培养物和脱髓鞘后的衰老大鼠给予RXR激动剂9-顺式-视黄酸能够增加轴突髓鞘再生。
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- 20. The electrophysiological feature was demyelination (93. 5% ), pathological features of sural nerve biopsy were segmental demyelination and mononuclear cell infiltration (100% ).
- 电生理表现脱髓鞘特征（93．5％），病理上表现为节段性脱髓鞘和单核细胞浸润（100％）。
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- 21. Rapid correction of chronic osmolar imbalance, especially in the presence of concurrent malnutrition, can cause rapid demyelination. This can also occur with normal serum sodium.
- 慢性渗透失衡的快速修正，尤其是在合并有营养不良的情况下，能够引起急进性脱髓鞘改变。也可以发生在血清钠正常的情况下。
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- 22. Some new foundation about the research that studied the relationship between the auditory neuropathy and the auditory nerve's demyelination leaded by quiescence of MPZ gene was provided.
- 为听神经病与MPZ基因的沉寂诱导的听神经脱髓鞘的相关性研究方面提供了部分新的依据。
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- 23. Abnormal enhancement is not seen in PMD as opposed to some demyelinating disorders such as adrenal leukodystrophy in which enhancement is seen at the periphery of the active demyelination.
- PMD中不会有异常的强化，相反其他的脱髓鞘病变如肾上腺脑白质营养不良症其外周活动性的脱髓鞘病变可以强化。
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- 24. The diagnosis in this case was tumefactive demyelination, which may be thought of as a solitary demyelinating lesion measuring greater than 2 cm and with characteristics that mimic neoplasm.
- 本例的诊断是肿瘤样脱髓鞘病变，这被认为是一种孤立的脱髓鞘病变，大小超过2cm，其特征类似于肿瘤样病变。
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- 25. The main reason responsble to leukoaraiosis was ischemia in white matter leading to neuroglia degeneration and demyelination. Leukoaraiosis may cause or deteriorate disturbance of intelligence.
- 白质小动脉缺血导致神经胶质细胞变性和白质纤维髓鞘脱失是发生白质疏松的主要原因，它可能导致或加重智能障碍。
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- 26. No difference could be detected in the demyelination between painless lingual nerve and painful inferior alveolar nerve ( P >0 05)Vessel wall of artery were seen thickened and cavity became smaller.
- 无痛的舌神经与疼痛的下牙槽神经末梢支脱髓鞘程度无显著性差异（P>0 .0 5 ）。
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- 27. No difference could be detected in the demyelination between painless lingual nerve and painful inferior alveolar nerve ( P >0 05)Vessel wall of artery were seen thickened and cavity became smaller.
- 无痛的舌神经与疼痛的下牙槽神经末梢支脱髓鞘程度无显著性差异（P>0 .0 5 ）。
youdao
- Oligodendrocyte damage and subsequent axonal demyelination is a hallmark of this disease.
少突胶质细胞损害，继而轴突脱髓鞘为本病特征。 - These cells may be a potential source for transplantation in the treatment of disorders of demyelination in humans.
这种早期培养的神经干细胞有形成髓鞘的能力，可作为治疗人类脱髓鞘病变的潜在细胞来源。
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